Broncos vs Chargers: Complete Game Preview, Analysis & Predictions for Week 3 AFC West Showdown

The AFC West division race takes center stage this Sunday as the Denver Broncos (1-2) travel to face the Los Angeles Chargers (3-0) at SoFi Stadium in what promises to be a pivotal Week 3 matchup. With the traditional powerhouse Kansas City Chiefs stumbling early this season, both teams see this as an opportunity to make a statement in the competitive AFC West.

Game Details & How to Watch

• Date: Sunday, September 21, 2025
• Time: 4:05 PM ET
• Location: SoFi Stadium, Inglewood, California
• TV: CBS
• Streaming: Paramount+
• Spread: Chargers -2.5
• Over/Under: 46 points

Denver Broncos: Seeking Consistency Under Sean Payton

The Broncos enter this contest looking to bounce back from a heartbreaking Week 2 loss to the Indianapolis Colts. After holding a 28-20 lead in the third quarter, Denver's inability to close out games continues to haunt them under second-year head coach Sean Payton.

Key Players to Watch

Bo Nix has shown flashes of brilliance in his rookie campaign, including a spectacular 52-yard touchdown pass to Courtland Sutton that gave the team life in their recent matchup. The rookie quarterback's development remains crucial to Denver's success moving forward.

Courtland Sutton continues to be Nix's favorite target, providing the veteran leadership and reliable hands the young quarterback needs. His chemistry with Nix could be the difference-maker in this divisional showdown.

Los Angeles Chargers: Riding High Under Jim Harbaugh

The Chargers have looked like a completely different team under new head coach Jim Harbaugh, starting the season with an impressive 3-0 record. Their dominant performances against division rivals Kansas City and Las Vegas have established them as early favorites for the AFC West crown.

Justin Herbert's MVP Campaign

Justin Herbert has been nothing short of spectacular through the first two weeks, throwing for 560 yards and five touchdowns without a single interception. The former Oregon star appears to have found his rhythm in Harbaugh's offensive system, making him an early MVP candidate.

The Chargers' balanced offensive attack, combined with an improved defense, has created the perfect storm for their early season success.

Historical Rivalry: Broncos vs Chargers

The Broncos-Chargers rivalry dates back to the AFL's inception in 1960, with both teams sharing divisional competition throughout their history. Denver currently leads the all-time series 73-57-1, but Los Angeles swept the season series in 2024, indicating a shift in momentum.

This rivalry has produced memorable moments over the decades, from dramatic playoff encounters to last-second finishes that have shaped AFC West history.

Coaching Matchup: Payton vs Harbaugh

The sideline battle between Sean Payton and Jim Harbaugh adds another layer of intrigue to this matchup. Harbaugh holds a historical advantage over Payton, going 3-1 against him during his previous stint with the San Francisco 49ers, including a memorable NFC divisional playoff victory in 2011.

Payton's offensive genius meets Harbaugh's defensive-minded approach in what should be a fascinating chess match between two of the NFL's most respected coaches.

Key Matchups to Watch

Broncos Pass Rush vs Chargers Offensive Line

Denver's pass rush, led by Nik Bonitto and Jonathon Cooper, will test Los Angeles' protection schemes. Bonitto has already recorded multiple sacks this season and will look to pressure Herbert into mistakes.

Chargers Running Game vs Broncos Run Defense

The emergence of running back J.K. Dobbins in Denver's backfield adds an interesting subplot, as he faces his former team. Dobbins' inside knowledge of the Chargers' defensive schemes could provide valuable advantages.

Injury Report & Impact Players

Denver will be without tight end Evan Engram (back injury), which could limit their red zone effectiveness. However, the return of Nate Adkins provides depth at the position.

Los Angeles appears relatively healthy entering this contest, giving them a potential advantage in terms of depth and rotation options.

Predictions & Analysis

This game could very well determine the early trajectory of the AFC West race. The Chargers' home field advantage at SoFi Stadium, combined with their perfect start and Herbert's exceptional play, makes them slight favorites.

However, Denver's resilience and Payton's ability to make in-game adjustments keep them competitive in any matchup. The Broncos' ability to avoid the penalty issues that plagued them in previous games will be crucial.

Final Prediction

Los Angeles Chargers 24, Denver Broncos 21

Expect a close, hard-fought divisional battle that comes down to the final possession. Herbert's consistency gives the Chargers the edge, but don't be surprised if this game requires overtime to decide a winner.

Frequently Asked Questions

What time does Broncos vs Chargers kick off?

The game kicks off at 4:05 PM ET on Sunday, September 21, 2025, at SoFi Stadium in Los Angeles.

Where can I watch Broncos vs Chargers?

The game will be broadcast on CBS nationally, with streaming available on Paramount+. Local markets will have their respective broadcasts.

Who is favored to win Broncos vs Chargers?

The Los Angeles Chargers are 2.5-point home favorites according to most sportsbooks, with the over/under set at 46 points.

How many times have these teams played each other?

The Broncos and Chargers have met 131 times since 1960, with Denver leading the all-time series 73-57-1.

What are the playoff implications of this game?

While it's early in the season, this AFC West matchup could have significant implications for division standings and wild card positioning, especially with Kansas City's slow start.

Conclusion: A Pivotal AFC West Showdown

Sunday's Broncos vs Chargers matchup represents more than just another week in the NFL schedule. With divisional supremacy and playoff positioning at stake, both teams understand the importance of this early-season contest.

The Chargers' perfect start puts them in the driver's seat, but Denver's veteran coaching and young talent make them dangerous opponents. Regardless of the outcome, this game will provide valuable insights into both teams' championship aspirations.

Don't miss this exciting AFC West battle! Make sure to tune in at 4:05 PM ET on CBS for what promises to be an unforgettable divisional showdown between two teams fighting for conference supremacy.